C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/01 (2006.01) C12N 5/071 (2010.01) C12N 5/12 (2006.01) C12N 15/00 (2006.01) C12P 1/00 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2649698
Whole Genome Evolution Technology can be considered a broad tool for supporting the needs for scaleable manufacturing of therapeutic antibodies. Its random nature and in vivo mode of action separate this process from other complementary technologies, thus providing alternative solutions to improve a host cell's manufacturing performance. The speed with which a pre-existing production strain can be optimized makes this process suitable for satisfying the current need for rapid cell line optimization to produce faster growing cells exhibiting high titers of antibody at the preclinical, clinical or commercialization stage.
L'innovation concerne la technologie d'évolution du génome entier considérée comme un vaste outil permettant de supporter les besoins d'une fabrication modulable d'anticorps thérapeutiques. Sa nature aléatoire et son mode d'action in vivo séparent ce procédé d'autres technologies complémentaires, fournissant ainsi des solutions alternatives permettant d'améliorer la performance de fabrication d'une cellule hôte. La vitesse avec laquelle une souche de production préexistante peut être optimisée rend ce procédé approprié pour satisfaire le besoin actuel d'une optimisation rapide de lignée cellulaire visant à produire des cellules à croissance plus rapide, présentant des titres élevés d'anticorps à l'étape préclinique, clinique ou de commercialisation.
Chao Qimin
Grasso Luigi
Kline J. Bradford
Nicolaides Nicholas C.
Sass Philip M.
Gowling Lafleur Henderson Llp
Morphotek Inc.
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