Withania somnifera composition

Details Withania somnifera composition Withania somnifera composition

A - Human Necessities

61

K

A61K 35/78 (2000.01)

Patent

CA 2374929

A high purity Withania Somnifera extract composition in the form of a high purity, stable, free-flowing, light yellow-to-brown herbaceous powder, for producing an enhanced cognition effect for the user and to augment the learning facility in the geriatric population when taken in a dosage of 200- 800 mg/day. This extract contains, by weight, (a) at least 3% of withanolide glycosides and sitoindosides, preferably 3-8%, (b) at least 3% of oligosaccharides, preferably 3-8%, preferably a molecular weight of < 2000, and (c) less than 0.5% of free cytotoxic withaferin A (aglycone), wherein the ratio of (a):(c) is 75-95:25-5, and the ratio of (a):(b) is 40-60:60-40. An extraction process for obtaining such extract composition, and pharmaceutical and nutritional use products thereof, also are described.

L'invention concerne une composition d'extrait de Somnifera Withania de haute pureté, se présentant sous la forme d'une poudre herbacée de haute pureté, stable, fluide, de couleur jaune-clair à brun, destinée à produire un effet de cognition accru pour l'utilisateur et à augmenter la facilité d'apprentissage chez des populations gériatriques, lorsqu'elle est prise en des doses de 200-800 mg/jour. Cet extrait renferme, en poids, (a) au moins 3 % de withanolide glycosides et sitoindosides, de préférence 3-8 %, (b) au moins 3 % d'oligosaccharides, de préférence 3-8 %, de préférence d'un poids moléculaire < 2000, et (c) moins de 0,5 % de withaférine A cytotoxique libre (aglycone), avec un rapport (a) :c) de 75-95 :25-5, et un rapport (a) :b) de 40-60 :60-40. L'invention concerne également un procédé d'extraction pour l'obtention d'une telle composition d'extrait, ainsi que des produits de celle-ci, à usage pharmaceutique et nutritionnel.

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