C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2306183
Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
La présente invention concerne des protéines à sécrétion induite par le Wnt-1 ou "WISP" (Wnt-1-Induced Secreted Proteins) dont les gènes sont induits au moins par le Wnt-1. L'invention concerne également des molécules d'acide nucléique codant ces polypeptides, ainsi que des vecteurs et des cellules hôtes comprenant ces séquences d'acide nucléique. L'invention concerne en outre des molécules de polypeptides chimériques comprenant ces polypeptides fusionnés à des séquences de polypeptides hétérologues, des anticorps qui se lient à ces polypeptides, et des procédés de production de ces polypeptides.
Botstein David A.
Cohen Robert L.
Goddard Audrey
Gurney Austin L.
Hillan Kenneth
Dennison Associates
Genentech Inc.
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