C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2662041
The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
La présente invention concerne des antagonistes de Wnt chimères comprenant un composant de domaine Frz dérivé d'une protéine Frizzled, une protéine connexe Frizzled secrétée ou une protéine Ror et un composant d'immunoglobuline Fc, et leur utilisation dans le traitement et la détection aux fins de diagnostic d'une signalisation Wnt cellulaire et de troubles à médiation Wnt, dont le cancer.
de Almeida Venita I.
Ernst James A.
Polakis Paul
Rubinfeld Bonnee
Genentech Inc.
Smart & Biggar
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