Wnt3a for inhibition of scarring

Details Wnt3a for inhibition of scarring Wnt3a for inhibition of scarring

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2678389

Provided is WNT3A, or a therapeutically effective fragment or derivative thereof, for use as a medicament for the prevention, reduction or inhibition of scarring. Also provided is a method of preventing, reducing or inhibiting scarring, the method comprising administering a therapeutically effective amount of WNT3A, or a therapeutically effective fragment or derivative thereof, to a patient in need of such prevention, reduction or inhibition. The methods and medicaments of the invention are suitable for use in the prevention, reduction or inhibition of scarring arising as a result of healing of a wound, or scarring associated with a fibrotic disorder. The methods and medicaments disclosed are of particular use in preventing, reducing or inhibiting scarring of the skin.

L'invention concerne l'utilisation de WNT3A, ou d'un fragment ou d'un dérivé thérapeutiquement efficace de celui-ci, comme médicament pour prévenir, réduire ou inhiber la formation de cicatrice. L'invention concerne également une méthode destinée à prévenir, réduire ou inhiber la formation de cicatrice, cette méthode consistant à administrer une dose thérapeutiquement efficace de WNT3A, ou d'un fragment ou d'un dérivé thérapeutiquement efficace de celui-ci, à un patient ayant besoin d'un tel traitement. Les méthodes et les médicaments de l'invention peuvent être utilisés pour prévenir, réduire ou inhiber la formation de cicatrice résultant de la cicatrisation d'une plaie, ou la formation de cicatrice liée à un trouble fibrotique. Ces méthodes et ces médicaments sont particulièrement utiles pour prévenir, réduire ou inhiber la formation d'une cicatrice cutanée.

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