Wnt4 in supporting lymphopoiesis

Details Wnt4 in supporting lymphopoiesis Wnt4 in supporting lymphopoiesis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12N 5/02 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2623874

The T lineage differentiative potential of lymphoid progenitor cells in the lymph nodes is thwarted by the absence of Wnt signaling, resulting in blockade of the DN1.fwdarw.DN2 transition with accumulation of pre-DN2 cells. Wnt4transcripts are deficient in the lymph nodes relative to the thymus. When cultured with stromal cells expressing thymus~like amounts of Wnt4 transcripts, lymphoid progenitor cells expand vigorously and generate single- positive T cells. Wnt4 can be used to promote the differentiation of lymphoid progenitors into cells such as T lymphocytes.

Selon cette invention, le potentiel de différenciation de lignées T de cellules progéniteurs lymphoïdes dans les noeuds lymphatiques est inhibé par l'absence de signalisation Wnt, ce qui bloque la transition de DN1 en DN2 et entraîne l'accumulation de cellules pré-DN2. Des transcrits Wnt4 sont défaillants dans les noeuds lymphatiques par rapport au thymus. Lorsqu'elles sont mises en culture avec des cellules stromales exprimant des quantités de type thymus de transcrits Wnt4, les cellules progéniteurs lymphatiques grossissent vigoureusement et génèrent des lymphocytes T positifs simples. On peut utiliser Wnt4 pour promouvoir la différenciation de progéniteurs lymphatiques en cellules telles que des lymphocytes T.

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