Wnv core protein/capsid interacting protein and uses of the...

Details Wnv core protein/capsid interacting protein and uses of the... Wnv core protein/capsid interacting protein and uses of the...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2448104

Substantially pure WIP-1 and its use in assays to identify PAP-l/WIP-1 interaction inhibitors or WIP-I/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WlP-1 and methods of treating cancer using the same are disclosed.

L'invention concerne la protéine WIP-1 sensiblement pure et l'utilisation de celle-ci dans des procédé permettant l'identification d'inhibiteurs de l'interaction PAP-l/WIP-1 ou d'inhibiteurs de l'interaction WIP-I/WNV Cp. L'invention concerne en outre des compositions comprenant des séquences antisens empêchant l'expression de WlP-1 et des traitements anti-cancéreux dans lesquels ces compositions sont utilisées.

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