Wortmannin analogs and methods of using same in combination...

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/35 (2006.01) C07D 311/78 (2006.01)

Patent

CA 2578336

Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer.

L'invention concerne des analogues de Wortmannin et leur utilisation dans l'inhibition de l'activité de la PI-3-kinase chez les mammifères, et le traitement du cancer et la formation de tumeurs chez un sujet. Lesdits analogues peuvent être utilisés avec d'autres agents chimiothérapeutiques dans le traitement du cancer.

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