Wortmannin-rapamycin conjugate and uses thereof

Details Wortmannin-rapamycin conjugate and uses thereof Wortmannin-rapamycin conjugate and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2678415

A rapamycin - wortmannin conjugate is described, in which the conjugate is formed by linking the rapamycin and wortmannin together in such a manner that the rapamycin and the wortmannin are separated following administration to a subject. Use of such a conjugate in an antineoplastic regimen is described.

L'invention concerne un conjugué de wortmannine-rapamycine, ce conjugué étant formé par la liaison de la rapamycine et de la wortmannine de sorte que la rapamycine et la wortmannine sont séparées après l'administration du conjugué à un sujet. L'invention concerne aussi l'utilisation d'un tel conjugué dans un traitement antinéoplasique.

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