Wound dressing comprising silver sulfadiazine incorporated...

Details Wound dressing comprising silver sulfadiazine incorporated... Wound dressing comprising silver sulfadiazine incorporated...

A - Human Necessities

61

K

167/102, 167/104

A61K 31/63 (2006.01) A61K 35/12 (2006.01) A61L 15/40 (2006.01) A61L 15/46 (2006.01) A61L 27/36 (2006.01) A61L 27/60 (2006.01)

Patent

CA 1219209

Wound Dressing Comprising Silver Sulfadiazine Incorporated in Animal Tissue Abstract of the Invention Animal tissue and the like having silver sulfa- diazine incoprorated therein is useful as a covering for burns and/or wounds. The silver sulfadiazine is incorporated in the tissue by soaking the tissue in an ammoniacal silver sulfadiazine solution or suspension. When the silver sulfadiazine is so incorporated in the tissue via an ammonium solution, more silver is found to be present than would normally be expected and the effectiveness of the thus treated tissue as a wound covering increases. Background of the Invention This invention relates to a process for preparing a dressing or covering for wounds and/or burns. Animal tissue has long been known to be a useful source of material for wound coverings. Although not identical to human skin, the composition and usefulness of some ani- mal tissue resembles human skin. For example, a covering for wounds, ideally, both protects the wound against contact with moisture and external contaminants, while also being permeable to the excretions, in particular, water vapor, which are produced by normal metabolic processes. Silver sulfadiazine (AgSD) is known as a useful antimicrobial in the treatment of wounds, and of burns in particular, see U. S. patent 3,761,590 (1973), Fox; Bose, Storing Amniotic Membrane in Silver Sulfadiazine Suspension, The Canadian Medical Assocation Journal, 127, No. 2, p. 112 (July 15, 1982); Fox, Modak and Stanford, Silver Treated Graft Materials for Coverage

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