A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/36 (2006.01) A61K 38/36 (2006.01) A61L 27/38 (2006.01) A61L 27/60 (2006.01) A61P 17/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2555233
The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterised by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3al and smooth muscle actin than the house~keeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
L'invention se rapporte à des compositions et à des méthodes de régénération tissulaire, destinées en particulier à traiter les lésions cutanées telles que les plaies. Un aspect de cette invention concerne une composition de cicatrisation des plaies caractérisée par des niveaux d'expression de gènes de marqueurs phénotypique tels que l'apolipoprotéine D, la métalloprotéase matricielle 2, de collagène 3a1 et l'actine des muscles lisses, plus élevés que ceux de la protéine ribosomale L32 du gène ménager (house keeping gene). Ces compositions et ces méthodes sont indiquées en particulier pour assister le processus de cicatrisation des plaies, en particulier en cas de lésions ouvertes chroniques tardant à se cicatriser ou résistantes à la cicatrisation.
Batten Margaret
Johnson Penelope Ann
Kemp Paul
Mcwhan Michael
Shering Andrew
Bcf Llp
Dfb Technology Holdings Llc
Intercytex Limited
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