A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61L 15/44 (2006.01) C07F 9/38 (2006.01)
Patent
CA 2689538
The invention provides a dressing composition comprising a bisphosphonate matrix metalloproteinase (MMP) inhibitor covalently bound to a polymer wherein, when the dressing is contacted with a wound, substantially all of the bisphosphonate remains with the dressing composition and is unable to enter the wound tissue. The invention also provides for a method of treatment of a wound by contacting a dressing composition comprising a covalently bound MMP inhibitor with the wound fluid to thereby selectively inhibit one or more MMP's in the wound fluid without inhibiting those in the wound tissue.
L'invention concerne une composition de pansement comprenant un inhibiteur de métalloprotéinase matricielle bisphosphonate (MMP) lié de manière covalente à un polymère. Lorsque le pansement est en contact avec une blessure, sensiblement tout le bisphosphonate reste dans la composition de pansement et ne peut pas entrer dans le tissu de blessure. L'invention concerne également un procédé de traitement d'une blessure par mise en contact d'une composition de pansement comprenant un inhibiteur de MMP lié de manière covalente avec le fluide de blessure, ce qui permet d'inhiber sélectivement une ou plusieurs MMP dans le fluide de blessure sans inhiber celles du tissu de blessure.
Dargaville Tim
Rayment Erin A.
Upton Zee
Moffat & Co.
Queensland University Of Technology
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