Wound treatment through inhibition of adenosine diphosphate...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/12 (2006.01) A61K 31/335 (2006.01)

Patent

CA 2329160

The present invention pertains to a method for healing a wound in a mammal which comprises the steps of (A) providing a therapeutic wound healing composition comprising a therapeutically effective amount of an inhibitor of mono-adenosine diphosphate-ribosyl transferase to inhibit adenosine diphosphate-ribosylation of vascular endothelial growth factor, and (B) contacting the therapeutic wound healing composition with a wound in a mammal. This invention also pertains to wound healing compositions and to methods for preparing and using the wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used. This invention further pertains to therapeutic dermatological-wound healing compositions useful to minimize and treat diaper dermatitis and to methods for preparing and using the therapeutic dermatological-wound healing compositions.

L'invention concerne une méthode permettant de soigner une blessure chez un mammifère. Cette méthode consiste à utiliser une composition thérapeutique de régénération des blessures comprenant une quantité efficace du point de vue thérapeutique d'un inhibiteur de mono-adénosine diphosphate-ribosyl transférase, de manière à inhiber l'adénosine diphosphate-ribosylation du facteur de croissance de l'endothélium vasculaire. Cette méthode consiste également à mettre en contact la composition thérapeutique de régénération des blessures avec une blessure d'un mammifère. L'invention concerne également des compositions de régénération des blessures ainsi que des méthodes de préparation et d'utilisation de ces compositions et des produits pharmaceutiques dans lesquels ces compositions peuvent être utilisées. L'invention concerne en outre des compositions thérapeutiques de régénération des blessures cutanées utiles pour traiter et atténuer les effets de l'érythème fessier du nourrisson ainsi que des méthodes de préparation et d'utilisation de ces compositions.

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