C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61P 29/00 (2006.01) C07K 14/54 (2006.01) C07K 14/705 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2657934
Compositions and methods relating to WSX-1 and p28 (IL-30) are provided. In particular, methods of treating inflammatory conditions in mammalian subjects using various WSX-1, p28, EBI3, and gp130 polypeptides and complexes or moieties that bind to or modulate activity of such complexes are described. Isolated or recombinant complexes including soluble WSX-1 or gp130 polypeptides, isolated or recombinant WSX-1 fusion proteins, and isolated or recombinant p28 fusion proteins are also described.
L'invention concerne des compositions et des méthodes se rapportant à WSX-1 et à p28 (IL-30). Elle concerne en particulier des méthodes de traitement d'états inflammatoires chez des sujets mammifères, qui mettent en oeuvre divers polypeptides et complexes WSX-1, p28, EBI3 et gp130, ou des fragments qui se lient auxdits complexes ou en modulent l'activité. L'invention concerne en outre des complexes isolés ou recombinants comprenant des polypeptides WSX-1 ou gp130 solubles, des protéines hybrides WSX-1 isolées ou recombinantes et des protéines hybrides p28 isolées ou recombinantes.
Hunter Christopher A.
Stumhofer Jason Scott
Mbm Intellectual Property Law Llp
The Trustees Of The University Of Pennsylvania
LandOfFree
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