A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2425072
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
L'invention concerne des compositions et des méthodes de thérapie de maladies malignes telles que la leucémie et le cancer. Les compositions contiennent un ou plusieurs des éléments comprenant un polynucléotide WT1, un polypeptide WT1, une cellule de présentation d'antigène présentant un polypeptide WT1, un anticorps se fixant spécifiquement à un polypeptide WT1; ou un lymphocyte T réagissant spécifiquement avec un polypeptide WT1. Ces compositions peuvent être utilisées, par exemple, dans la prévention et le traitement de maladies métastatiques.
Boydston Jeremy
Evans Lawrence
Gaiger Alexander
Mcneill Patricia D.
Mossman Sally
Corixa Corporation
Gaiger Alexander
Gowling Lafleur Henderson Llp
LandOfFree
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