Wt1 monoclonal antibodies and methods of use therefor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/16 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2188663

The present invention provides three unique monoclonal antibodies directed against a portion of the Wilms' tumor antigen, and methods of use therefor in detecting, monitoring and diagnosing malignancies characterized by over-expression or inappropriate expression of the WT1 protein.

L'invention porte sur trois anticorps monoclonaux singuliers agissant contre une portion de l'antigène de la tumeur de Wilms, et sur des méthodes d'utilisation en vue du dépistage, du suivi et du diagnostic de tumeurs malignes caractérisées par une surexpression ou une expression inappropriée de protéines du WT1.

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