X-ray contrast agents

Details X-ray contrast agents X-ray contrast agents

A - Human Necessities

61

K

260/509.5

A61K 49/04 (2006.01)

Patent

CA 1048536

ABSTRACT OF THE DISCLOSURE 3,6,9-trioxaundecane-1,11-dioyl-bis-(3-carboxy-2,4,6- triiodo-anilide) of the formula Image and salts thereof with bases are X-ray contrast agents and are produced by reacting 3-amino-2,4,6-triiodo-benzoic acid with a reactive derivative, e.g., acid halide or mixed anhydride of 3,6,9-trioxaundecane-1,11-dioyl-bis-(3-carboxy-2,4,6-triiodo- anilide). The reaction is carried out in a polar solvent, e.g., chlorobenzene, dioxane, dimethylacetamide, dimethylformamide or acetonitrile at a temperature of 0 to 150°C, preferably 20 to 120°C.

219351

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