X-ray contrast compositions and method for their use in the...

A - Human Necessities – 61 – K

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A61K 49/04 (2006.01)

Patent

CA 2093083

ABSTRACT Disclosed is an orally or rectally administrable X-ray contrast formulation in the form of an aqueous dispersion or emulsion for X-ray examination of the gastrointestinal tract, comprising: (A) 1 to 50% w/v of a non-aqueous phase; (B) 0.001 to 75% w/v of an iodine-containing X-ray contrast agent having the formula: Image (I) (wherein: R is an alkyl group containing from 2 to 8 carbon atoms which is unsubstituted or substituted by a C1-C6 alkyl, hydroxyl or C1-C6 alkoxy substituent; and n is an integer of 1 to 5); (C) 0 to 10% w/v of at least one surfactant; (D) 0 to 20% w/v of at least one physiologically acceptable excipient, not including the surfactant (C); and (E) water in an amount more than 0 and sufficient to make the total 100% w/v and a method of its use in diagnostic radiology of the gastrointestinal tract.

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