X-ray contrast formulation comprising a mixture of iodinated...

A - Human Necessities – 61 – K

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A61K 49/04 (2006.01)

Patent

CA 2559628

The present invention generally relates to nonionic x-ray contrast media formulations, radiological compositions containing such agents and methods for x-ray visualization utilizing such compositions. The invention especially relates to injectable radiological compositions for x-ray visualization comprising a pharmaceutically acceptable vehicle and a mixture of a monomer, being a triiodo-substituted benzene nucleus, and a dimer, being two linked triiodo-substituted benzene nuclei, such that the mixture demonstrates favorable properties.

De manière générale, la présente invention a trait à des formulations de milieux de contraste de rayons X non ioniques, des compositions contenant de tels agents et des procédés pour la visualisation par rayons X mettant en oeuvre de telles compositions. L'invention a trait plus particulièrement à des compositions radiologiques injectables pour la visualisation par rayons X comportant un support pharmaceutiquement acceptable et un mélange d'un monomère, consistant en un noyau benzénique à substitution triiodo, et un dimère, consistant en deux noyaux benzéniques liés à substitution triiodo, de sorte que le mélange présente des propriétés favorables.

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