X-ray guided drug delivery

A - Human Necessities – 61 – K

Patent

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Details

A61K 51/00 (2006.01) A61K 9/127 (2006.01) A61K 41/00 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/02 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2368748

A method of delivering an active agent to a target tissue, particularly neoplastic tissue, vascular anomaly or tumor tissue, in a vertebrate subject. The method includes the steps of exposing the target tissue to ionizing radiation; and administering a delivery vehicle to the vertebrate subject before, after, during, or combinations thereof, exposing the target tissue to the ionizing radiation. The delivery vehicle includes the active agent and delivers the agent to the target tissue. Representative delivery vehicles include platelets; leukocytes; proteins or peptides which bind activated platelets; antibodies which bind activated platelets; microspheres coated with proteins or peptides which bind activated platelets; liposomes conjugated to proteins or peptides, platelets, or leukocytes which bind activated platelets, or antibodies which bind activated platelets; and combinations thereof.

L'invention concerne un procédé pour l'administration d'un principe actif à un tissu cible, en particulier un tissu néoplastique, une anomalie vasculaire ou un tissu tumoral, chez un sujet vertébré. Le procédé selon l'invention comprend les étapes suivantes : exposition du tissu cible à un rayonnement ionisant et administration d'un vecteur d'administration au sujet vertébré avant ou après ou pendant exposition du tissu cible au rayonnement ionisant. Le vecteur d'administration contient le principe actif et le libère dans le tissu cible. Des vecteurs d'administration représentatifs incluent des plaquettes, des leucocytes, des protéines ou peptides liant des plaquettes activées, des anticorps liant des plaquettes activées, des microsphères revêtues de protéines ou peptides liant des plaquettes activées, des liposomes conjugués à des protéines ou peptides, plaquettes ou leucocytes liant des plaquettes activées ou anticorps liant des plaquettes activées, et des combinaisons de ces éléments.

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