Xanthene and acridine derivatives and their use

Details Xanthene and acridine derivatives and their use Xanthene and acridine derivatives and their use

C - Chemistry, Metallurgy

07

D

C07D 219/06 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 311/86 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2210415

The invention relates to new and known tricyclic dione derivatives of the general formula (see fig. I) wherein W represents hydrogen or lower alkyl; X represents lower alkyl; Y represents an oxygen atom or NR1; R1 represents hydrogen, lower alkyl, lower alkoxycarbonyl or lower alkoxycarbonyl-lower alkyl; Z represents aryl or heteroaryl optionally substituted by one or more halo, cyano, nitro, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, COR2, OCOR2, CO2R2, OR2, S(O)nR2, NR2R3, N(R4)COR5, Ar, Ar-lower alkyl, Het or Het-lower alkyl substituents and/or on adjacent carbon atoms by lower alkylenedioxy; R2, R3, R4 and R5 each individually represent hydrogen, lower alkyl, Ar, Ar-lower alkyl, Het or Het-lower alkyl substituents; or R2 and R3 together represent the group -CH=CH-CH=CH- or -CH=N-CH=CH-; Ar represents aryl optionally substituted by one or more halo, lower alkyl, lower alkoxy or nitro substituents; Het represents heteroaryl optionally substituted by one or more halo, lower alkyl, lower alkoxy or nitro substituents; and n stands for 0, 1 or 2 and to their salts which are inhibitors of herpes simplex virus thymidine kinase in the treatment and prophylaxis of infections caused by herpes simplex virus.

L'invention porte sur des dérivés de diones tricycliques, nouveaux et connus, de formule générale (voir fig. I), où W représente de l'hydrogène ou un alkyle inférieur; X est un alkyle inférieur; Y est un atome d'oxygène ou NR1; R1 est un hydrogène, un alkyle inf., un alcoxycarbonyle inf. ou un alcoxycarbonyle inf.-alkyle inf.; Z est un aryle ou un hétéroaryle avec substitution facultative par un ou plusieurs halo, cyano, nitro, alkyle inf., halo-alkyle inf., alcoxy inf., halo-alcoxy inf., COR2, OCOR2, CO2R2, OR2, S(O)nR2, NR2R3, N(R4)COR5, Ar, Ar-alkyle inf., Het ou Het-alkyle inf. et (ou), sur des atomes de carbone adjacents, par un alkylènedioxy inf.; R2, R3, R4 et R5 représentent chacun un hydrogène, un alkyle inf., Ar, Ar-alkyle inf., Het ou Het-alkyle inf.; ou R2 et R3 représentent ensemble le groupe -CH=CH-CH=CH- ou -CH=N-CH=CH-; Ar est un aryle avec substitution facultative par un ou plusieurs halo, alkyle inf., alcoxy inf. ou nitro; Het représente un hétéroaryle avec substitution facultative par un ou plusieurs halo, alkyle inf., alcoxy inf. ou nitro; n est 0, 1 ou 2; et sur leurs sels, inhibiteurs de la thymidine-kinase du virus de l'herpes simplex dans le traitement et la prévention des infections causées par ce virus.

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