Xanthine derivatives

Details Xanthine derivatives Xanthine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/06 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2082325

- 44 - Abstract of the disclosure: A novel xanthine derivative of the formula (I): Image (I) wherein one of R1 and R2 represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted benzyl; and the other represents -(CH2)m-X wherein m is 2 or 3, and X is Image where a is NH, O or S, and b and d are the same or different and are CH or N or Image -45- where e, g and h are the same or different and are CH or N; Q represents Image (wherein R3 and R4 are the same or different and are substituted or unsubstituted alicyclic alkyl), Image (wherein Y is a single bond or alkylene, n is 0 or 1), Image (wherein ---- is a single or double bond. Y is the same as defined above), or Image (wherein Y is the same as defined above); or a pharmacologically accetable salt thereof is disclosed. This derivative has anti-dementia activity.

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