C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.4
C07D 473/06 (2006.01)
Patent
CA 1075692
A B S T R A C T This invention relates to a process for the preparation of the compounds of general formula Image (I) wherein R1 is an (.omega.-1)-oxoalkyl group containing from 5 to 7 carbon atoms, R2 is methyl and R3 is propyl, and physiologically acceptable acid addition salts thereof, which comprises a) reacting an alkali metal salt of a 3-methyl-7-alkyl xanthine with a substance selected from the group consisting of a 1) a compound of formula Image (III) wherein A is an alkylene group containing from 3 to 5 carbon atoms and Hal is a halogen atom; b 1) an acetal, c 1) ketal and d 1) thioketal therefrom and subsequently hydrolysing the product or b) reacting an alkali metal salt of 1-(.omega.-1)-oxoalkyl-3-methyl- xanthine wherein the oxoalkyl radical has from 5 to 7 carbon atoms with a propylating compound selected from the group consisting of propyl halides and a propyl sulphate in the presence of a solvent, c) reacting a compound of formula (IV) Image herein X is an alkylene group containing from 3 to 5 carbon atoms and Hal is a halogen atom with an alkali metal salt of an acetoacetate and subse- quently subjecting the reaction product to ketone splitting to obtain a product of general formula (I) as defined above, or d) oxidation of a compound of formula Image (V) wherein R2 and R3 have the meaning as defined above and Y is an (.omega.-1)-hydroxy- alkyl group having from 5 to 7 carbon atoms, and wherein the product obtained is isolated per se or reacted with an acid to form a physiologically compat- ible acid addition salt thereof. It also relates to the products of this process which are useful in the treatment of diseases involving deficiencies in the blood vascular system.
320437
Jayme Manfred
Komarek Jaromir
Mohler Werner
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