Xanthine derivatives

Details Xanthine derivatives Xanthine derivatives

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/18 (2006.01) A61K 31/52 (2006.01) C07D 473/06 (2006.01) C07D 473/08 (2006.01) C07D 473/12 (2006.01)

Patent

CA 1289954

Case 100-6955 ABSTRACT A compound of formula I Image (I) wherein R1 is C1-4alkyl, C3-4alkenyl or (C3-5cycloalkyl)-methyl, R2 is C1-4alkyl, [hydroxy- or (C1-4alkoxy)-substituted C1-3alkyl]-methyl, (C3-5cycloalkyl)-methyl, tetrahydrofuran- 2-yl-methyl or 1,3-dioxolan-2-yl-methyl, R3 and R4 are each hydrogen, hydroxymethyl, methoxymethyl or N,N-dimethylcarba- moyloxymethyl, R5 is hydroxy or methoxy, R6 is hydrogen, hydroxy, methoxy or halogen and R7 is in the 2- or 3-position and is hydroxy, methoxy or halogen, or together with R5 is 3,4-methylendioxy, or together with R6 is 2,3-methylenedioxy and their physiologically-hydrolysable and -acceptable esters are useful in the treatment (symptomatic and prophylactic) of obstructive or inflammatory airways disease, in particular asthma, and disease characterised by or having an aetiology comprising morbid eosinophil accumulation or activation, e.g. hypereosinophilia.

545408

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