Xanthine derivatives as muscarinic receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) A61K 31/40 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2511726

This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0] hexanes. The compounds of this invention can function as muscarinic receptor antagonists, inter alia for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

La présente invention se rapporte à des dérivés d'azabicyclo[3.1.0] 3,6-disubstitués. Les composés de la présente invention peuvent être utilisés en tant qu'antagonistes des récepteurs muscariniques, notamment pour le traitement de diverses maladies des systèmes respiratoire, urinaire et gastrointestinal, maladies dont la médiation est assurée par les récepteurs muscariniques. L'invention se rapporte également à un procédé de préparation de ces composés, à des compositions pharmaceutiques contenant ces composés et à des méthodes de traitement des maladies dont la médiation est assurée par les récepteurs muscariniques.

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