Xanthine derivatives, processes for their production and...

Details Xanthine derivatives, processes for their production and... Xanthine derivatives, processes for their production and...

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/06 (2006.01) A61K 31/52 (2006.01) C07D 473/08 (2006.01) C07D 473/12 (2006.01)

Patent

CA 1266470

100-6690 ABSTRACT Xanthine derivatives of formula I Image wherein R1 is C1-4alkyl, C3-4alkenyl or C3-6cycloalkylmethyl,R2 is C1-4alkyl which is unsubstituted or substituted by one or more substituents selected from hydroxy, mercapto, C1-4alkoxy and C1-4alkylthio, R3 is hydrogen, halogen, hydroxy, C1-4alkoxy, amino or mono- or di-(C1-4alkyl)amino and R4 and R5 are each independently halogen, hydroxy, C1-4alkoxy, amino, mono- or di-(C1-4alkyl) amino or together represent a methylene dioxy group (-O-CH2-O-)-bridging adjacent positions on the phenyl ring, and the physiologically-hydrolysable and -acceptable esters and amides thereof; which compounds are indicated for use as pharmaceuticals in parti- cular for treating asthma and bronchitis.

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