C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/04 (2006.01) A61P 5/00 (2006.01) C07D 473/06 (2006.01) C07D 473/08 (2006.01) C07D 473/10 (2006.01) C07D 473/12 (2006.01)
Patent
CA 2435730
The present invention relates to substituted xanthines of general formula (see formula I) wherein R1 is, for example, H, optionally substituted alkyl, alkenyl, alkynyl, an aryl or a heterocylic group; R 2 is, for example, H, an optionally substituted alkyl or alkenyl, alkynyl cycloalkyl, an aryl or a heterocyclic group; R3 is, for example, optionally substituted alkyl, optionally substituted alkenyl, alkynyl, or aryl; and R4 is a substituted heterocyclic group; the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
La présente invention concerne des xanthines substituées de la formule générale (I) dans laquelle R?1¿ à R?4¿ présentent la signification donnée dans la revendication 1. L'invention concerne également les tautomères, les stéréoisomères, les mélanges, les promédicaments et les sels des xanthines selon l'invention présentant des propriétés pharmacologiques intéressantes, notamment une action inhibitrice sur l'activité de l'enzyme dipeptidylpeptidase-IV (DPP-IV).
Eckhardt Matthias
Himmelsbach Frank
Langkopf Elke
Lotz Ralf
Maier Roland
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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