Xanthine derivatives, their production and use

Details Xanthine derivatives, their production and use Xanthine derivatives, their production and use

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/02 (2006.01) A61K 31/52 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2031328

Abstract of the Disclosure Novel xanthine derivatives of the formula (I): Image (I) wherein R1, which may be optionally bound through a hetero atom, is a hydrocarbon residue which may be substituted; one of R2 and R3 is a hydrocarbon residue which may be substituted, and the other is hydrogen or a hydrocarbon residue which may be substituted; R4 is hydrogen, halogen or nitro; R5 is a residue capable of forming an anion or a residue convertible into the anion; A is a direct bond or a spacer having atomic length of two or less; n is an integer of 1 or 2; and Y and Z, which may be the same or different, are an oxygen atom or a sulfur atom; and the pharmaceutically acceptable salts thereof have potent angiotensin II antagonist activity and hypotensive activity, thus being useful as therapeutic agents for treating circulatory ststem diseases such as hypertensive diseases, heart diseases, strokes, etc.

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