Xanthine oxidase inhibition

Details Xanthine oxidase inhibition Xanthine oxidase inhibition

A - Human Necessities

61

K

A61K 31/519 (2006.01)

Patent

CA 2467240

Disclosed is a method for alleviating the oxidative impairment of vascular function by inhibiting the activity oxidases, or active forms thereof. Xanthine oxidases levels have been shown to be increased by a variety of conditions, including sickle cell disease. In the present disclosure, allopurinol is used to inhibit xanthine oxidase activity. As a result of the inhibition of xanthine oxidase, NO levels in a subject can be maintained. In addition to sickle cell disease, allopurinol inhibition of xanthine oxidase may be used to treat other conditions, including, but not limited to, respiratory distress, kidney disease, liver disease, ischemia-reperfusion injury, organ transplant, sespis, burns, viral infections and hemorrhagic shock.

L'invention concerne un procédé de soulagement d'une altération d'oxydation de la fonction vasculaire par inhibition de l'activité de la xanthine-oxydase, ou des formes actives de celle-ci. Il a été démontré que les niveaux de xanthine-oxydase ont augmenté selon divers états pathologiques, notamment une drépanocytose. Ledit procédé utilise de l'allopurinol pour inhiber l'activité de la xanthine-oxydase. L'inhibition de la xanthine-oxydase permet de maintenir les niveaux de NO chez un individu. En plus de la drépanocytose, l'inhibition d'allopurinol de xanthine-oxydase peut être utilisée pour traiter d'autres états pathologiques y compris, mais non exclusivement, des détresses respiratoires, des maladies des reins, des maladies du foie, des lésions d'ischémie-reperfusion, des transplants d'organes, des septicémies, des brûlures, des infections virales et des chocs hémorragiques.

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