C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C07K 14/47 (2006.01) C12N 15/53 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2333016
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals.
L'invention concerne une molécule isolée d'acide nucléique comprenant une séquence nucléotidique codant un amplificateur de transcription de production ou expression de cytochrome P450 (P459) CYP3A4. L'invention concerne également les utilisations de la molécule d'acide nucléique permettant le criblage de composés pour l'induction xénobiotique de l'expression de CYP3A4 dans les cellules et chez les animaux.
Goodwin Bryan James
Liddle Christopher
Oyen Wiggs Green & Mutala Llp
The University Of Sydney
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