Xenogeneic cholesteryl ester transfer protein (cetp) for...

Details Xenogeneic cholesteryl ester transfer protein (cetp) for... Xenogeneic cholesteryl ester transfer protein (cetp) for...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2307012

Methods for modulating cholesteryl ester transfer protein (CETP) activity and the plasma levels of lipoproteins involved in heart disease involve administration of a non-endogenous CETP or a plasmid-based vaccine for expression of such non-endogenous CETP to elicit production in a mammal of antibodies that recognize (bind to) the mammal's native (endogenous) CETP.

L'invention concerne des procédés permettant de moduler l'activité de la protéine de transfert de l'ester de cholestéryle et les taux plasmatiques des lipoprotéines impliquées dans les maladies cardiaques. Ce procédé consiste à administrer une protéine de transfert de l'ester de cholestéryle non endogène ou un vaccin à base de plasmide pour assurer l'expression de cette protéine de transfert de l'ester de cholestéryle non endogène afin d'induire, chez le mammifère, la production d'anticorps qui reconnaissent (ou se fixent à) la protéine de transfert de l'ester de cholestéryle endogène native.

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