Xenograft bone matrix for orthopedic applications

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/38 (2006.01) A61F 2/28 (2006.01) A61L 27/36 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01) A61F 2/46 (2006.01)

Patent

CA 2441888

The invention provides for the use of an improved xenograft bone particulate with respect to osteo-integration and bone remodeling, while diminishing the primate-to-pig immunological response using established bone-processing technique. Work was carried out using undecalcified bone to determine immunocompatibility and bone remodeling potential of processed porcine bone struts following onlay graft implantation. New bone formation was evident, including the infiltration of cellular materials responsible for fusion and bone reconstruction.

L'invention concerne l'utilisation d'une particule osseuse de xénogreffe améliorée par rapport à l'osto-intégration et le remodelage osseux, tout en diminuant la réaction immunologique du primate au porc au moyen de la technique de traitement osseux établie. Le travail a été effectué au moyen d'un os non décalcifié afin de déterminer l'immunocompatibilité et le potentiel de remodelage osseux des étais osseux porcins traités après une implantation par greffe apposée. Une formation osseuse nouvelle était évidente, de même que l'infiltration de matériaux cellulaires responsables de la fusion et de la reconstruction osseuse.

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