Xiap ires and uses thereof

Details Xiap ires and uses thereof Xiap ires and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/67 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2336707

The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap- independent translation.

L'invention concerne de l'acide nucléique purifié codant une nouvelle séquence IRES du gène inhibiteur de l'apoptose à liaison X (XIAP). L'invention concerne en outre des procédés relatifs à l'utilisation de la séquence IRES du gène XIAP, en vue d'augmenter la traduction indépendante de la coiffe pour les séquences de codage polypeptidiques liées à la séquence IRES du gène XIAP. L'invention concerne enfin des procédés relatifs à l'isolation de composés qui modulent la traduction susmentionnée.

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