Y2 selective receptor agonists for therapeutic interventions

Details Y2 selective receptor agonists for therapeutic interventions Y2 selective receptor agonists for therapeutic interventions

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 8/00 (2006.01) A61K 38/17 (2006.01) A61P 3/04 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2623094

The modified human PP peptides (i) [Lys4,Leul7,Ser30,G1n34]hPP, (ii) Lys4,Leul7,Thr3O,Gln34]hPP; and (iii) [Lys4,Leul7,oxidised Met30,Gln34]hPP wherein "oxidised Met" may be the sulfoxide or sulfone, and certain analogues and derivativatised forms thereof as referred to in the specification, are selective agonists of the Y2 receptor relative to the Y1 and Y4 receptors, and are useful for, for example, appetite control and therapeutic angiogenesis.

Les peptides PP humains modifiés (I) [Lys4, Leu17, Ser30, GIn34]hPP, (II) Lys4, Leu17, Thr30, Gln34]hPP, et (III) [Lys4, Leu17, Met30 oxydés, Gln34]hPP, où <= Met oxydés >= pouvant représenter sulfoxyde ou sulfone, et certains analogues et formes dérivées de ceux-ci étant définis dans la description, sont des agonistes sélectifs du récepteur Y2, associé au récepteurs Y1 et Y4, et s'utilisent notamment dans la régulation de l'appétit et l'angiogenèse thérapeutique.

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