Yeast-based delivery vehicles

Details Yeast-based delivery vehicles Yeast-based delivery vehicles

C - Chemistry, Metallurgy

12

N

C12N 1/19 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) C07K 14/16 (2006.01) C12N 9/60 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12N 15/81 (2006.01) C12N 15/82 (2006.01) C12Q 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2205379

The present invention includes yeast vehicles and their use as delivery vehicles. Yeast vehicles include a yeast portion and a heterologous compound. Such yeast vehicles can be used to protect animals from disease and to otherwise carry compounds to given cell types. Examples of yeast vehicles include gene delivery vehicles, drug delivery vehicles, and immunomodulatory vehicles. Immunomodulatory vehicles are capable of modulating an immune response. When stimulating an immune response, such yeast vehicles effect cell-mediated as well as humoral immunity.

Cette invention porte sur les véhicules à base de levure et leur utilisation pour l'acheminement. Les véhicules en question comportent une portion de levure et un composé hétérologue. Ils peuvent être utilisés pour protéger les animaux contre les maladies, ou bien pour acheminer des composés vers différents types de cellules. On peut citer comme exemples les véhicules qui acheminent les gènes, ceux qui acheminent les médicaments ou bien encore les véhicules immuno-modulateurs. Ces derniers sont capables de moduler une réponse immunitaire. Lorsqu'ils stimulent une réponse immunitaire, les véhicules à base de levure considérés dans la présente invention engendrent une immunité à médiation cellulaire et humorale.

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