Yeast-based therapeutic for chronic hepatitis c infection

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/70 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2584562

Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.

L'invention concerne des compositions, y compris des vaccins, et des procédés pour la vaccination d'animaux contre le virus de l'hépatite C (VHC) et pour le traitement ou la prévention de l'infection par ce virus chez l'animal. On décrit une série de protéines de fusion du VHC pouvant être utilisées directement comme vaccin ou en combinaison avec un vecteur de vaccin à base de levure visant à induire une réponse immunitaire contre le VHC chez l'animal. On décrit aussi l'utilisation du gène de fusion du VHC et de la protéine considérée dans tout protocole diagnostique ou thérapeutique pour la détection et/ou le traitement ou la prévention de l'infection par le VHC.

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