C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/40 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01) A61P 31/12 (2006.01) C07K 14/08 (2006.01) C12N 1/19 (2006.01) C12N 15/81 (2006.01)
Patent
CA 2428027
Disclosed are processes for producing a vaccine for use against infectious pancreatic necrosis virus (IPNV) in fish, which process comprises culturing a yeast host cell which expresses, and preferably secretes, an IPNV polypeptide, and formulating the polypeptide as a vaccine (preferably by using, or partially purifying) the supernatant. Such vaccines have advantages over vaccines produced in bacteria. Also disclosed are vaccines based VP3 and VP2var proteins, optionally in combination with antigens protective against other fish diseases. The invention further provides related materials (e.g. primers, vectors and host cells) and methods and uses of the vaccines for prophylaxis and therapy.
L'invention concerne des processus de production d'un vaccin pouvant être utilisé contre le virus de la nécrose pancréatique infectieuse (NPI) chez le poisson, processus consistant à cultiver une cellule hôte de levure qui exprime, et de préférence sécrète, un polypeptide du virus NPI, et à préparer le polypeptide comme vaccin (en utilisant de préférence, ou en purifiant partiellement, le supernageant). De tels vaccins présentent des avantages par rapport aux autres vaccins produits dans des bactéries. L'invention concerne également des vaccins à base de protéines VP3 et VP2var, associés de manière facultative à des antigènes protecteurs contre d'autres maladies du poisson. L'invention concerne encore des matériaux associés (par exemple des amorces, des vecteurs et des cellules hôtes), des procédés et des utilisations de ces vaccins dans la prophylaxie et le traitement.
Breeman Suzanne
Labus Marie Beagley
Melvin William Thomas
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The University Court Of The University Of Aberdeen
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