Yeast ectopically expressing abnormally processed proteins...

Details Yeast ectopically expressing abnormally processed proteins... Yeast ectopically expressing abnormally processed proteins...

C - Chemistry, Metallurgy

12

N

C12N 1/19 (2006.01) A61K 31/00 (2006.01) A61K 45/00 (2006.01) A61P 25/16 (2006.01) C12N 15/81 (2006.01) C12Q 1/02 (2006.01) C12Q 1/34 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2522497

Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast. Compounds identified by such screens can be used to treat or prevent diseases associated with abnormally processed proteins or protein misfolding. Such disease include Parkinson~s Disease, Parkinson~s Disease with accompanying dementia, Lewy body dementia, Alzheimer~s disease with Parkinsonism, and multiple system atrophy.

L'invention porte sur des protéines traitées anormalement et exprimant de manière ectopique la levure, ainsi que sur des procédés de criblage visant à identifier des composés qui modulent la fonction de ces protéines traitées anormalement dans la levure. Les composés identifiés par ces cribles peuvent être utilisés pour traiter ou prévenir des maladies associées à des protéines anormalement traitées ou au mauvais repliement des protéines. Ces maladies sont la maladie de Parkinson, la maladie de Parkinson accompagnée de démence, démence du corps de Lewy, maladie d'Alzheimer accompagnée de Parkinsonisme et atrophie du système multiple.

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