Yeast mutants

Details Yeast mutants Yeast mutants

C - Chemistry, Metallurgy

12

N

C12N 1/18 (2006.01) C12N 15/01 (2006.01) C12Q 1/18 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2068062

165/RJN105 18395Y TITLE OF THE INVENTION NEW YEAST MUTANTS ABSTRACT OF THE DISCLOSURE Disclosed is a process utilizing yeast mutants for identifying active FK-506 type immunosuppressants. The process utilizes Saccharomyces cerevisiae mutants containing an fkr1, fkr2, fkr3 mutant gene or mixture thereof, which are resistant to FK-506 but sensitive to rapamycin. These mutants can be used in a diagnostic procedure for identifying FK-506 and FK-506 type immunosuppressants and in screening assays for compounds and fermentation broths which exhibit FK-506 type immunosuppressive activity. Specifically disclosed are the new yeast mutants, Saccharomyces 165/RJN105 - ii - 18395Y cerevisiae YFK093, (Merck Culture Collection No. MY 2088) ATCC No. 74055, containing an fkr3 mutant gene, Saccharomyces cerevisiae YFK 012, (Merck Culture Collection No. MY 2096) ATCC No. 74061, which contains an fkr1 mutant gene, Saccharomyces cerevisiae YFK 014, (Merck Culture Collection No. MY 2097) ATCC No. 74062 and YFK-023-17A (Merck Culture Collection No. MY 2098) ATCC No. 74063, both which contain an fkr2 mutant gene and are useful in identifying active FK-506 type immunosuppressants.

Affiliated with

Also associated with

Rating

Yeast mutants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Yeast mutants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Yeast mutants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1666550