Yeast production of hepatitis b surface antigen

Details Yeast production of hepatitis b surface antigen Yeast production of hepatitis b surface antigen

C - Chemistry, Metallurgy

12

N

195/1.18, 195/1.

C12N 15/00 (2006.01) C07H 21/04 (2006.01) C07K 14/02 (2006.01) C12N 1/16 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1285895

Abstract of the Disclosure Novel DNA constructs comprising regulatory regions plus the structural coding region for hepatitis B surface antigen (HBsAg) are disclosed. The regulatory regions employed are responsive to methanol, non-catabolite repressing carbon sources and catabolite repressing carbon sources followed by carbon source starvation. The novel constructs are incorporated into a variety of linear and circular plasmids. Such plasmids are used to transform suitable hosts and ultimately used for the production and isolation of hepatitis B surface antigen in high yields.

513467

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