Yeast screens for agents affecting protein folding

Details Yeast screens for agents affecting protein folding Yeast screens for agents affecting protein folding

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2438661

Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.

L'invention concerne des méthodes permettant d'identifier des substances qui présentent une valeur thérapeutique pour différentes maladies associées à un mauvais repliement de certaines protéines. D'une manière plus spécifique, concerne des méthodes de criblage génétique et chimique faisant appel à un système de levure. Les méthodes selon l'invention constituent une méthode rapide et rentable de criblage permettant de déterminer des composés qui empêchent le mauvais repliement des protéines et/ou la formation de fibrilles sur des protéines et/ou l'accumulation de fibrilles sur des protéines qui se manifestent dans de nombreuses maladies neurodégénératives telles que la maladie de Parkinson, la maladie d'Alzheimer, la maladie de Huntington et des maladies non neuronales telles que le diabète de type II.

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