Yeast strain and methods for expressing heterologous...

Details Yeast strain and methods for expressing heterologous... Yeast strain and methods for expressing heterologous...

C - Chemistry, Metallurgy

12

N

C12N 1/19 (2006.01) C07K 14/535 (2006.01) C07K 14/65 (2006.01) C12N 1/18 (2006.01) C12N 15/18 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2161973

Saccharomyces cerevisiae strain, characterized in that it is defective in O-mannosylation of a hydroxyl group of at least one serine or at least one threonine residue in a protein expressed by the strain. In the preferred strains the protein is heterologous and encoded in a vector. Process for the production of a protein that normally is O-glycosylated by S. cerevisiae using the strain to express the protein.

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