C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/18 (2006.01) C12N 15/81 (2006.01) C12N 15/90 (2006.01) C12Q 1/04 (2006.01) C12Q 1/18 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2589754
The present invention provides modified yeast cell lines and their use in screening procedures for identifying inhibitors of the expression of the hexose transporter genes by a positive phenotype. It is especially suited to screen for substances that re-sensitize resistant pathogenic microorganisms or tumor cells by suspending the expression of resistance-relevant genes. The invention further provides methods for constructing said cell lines and their use in screening systems.
L'invention concerne des lignées cellulaires de levure modifiées et leur utilisation dans des processus de criblage servant à identifier des inhibiteurs de l'expression des gènes transporteurs d'hexose par un phénotype positif. Elle est particulièrement appropriée au criblage de substances resensibilisant des micro-organismes pathogènes résistants ou des cellules cancéreuses par suspension de l'expression de gène de résistance. Elle concerne également des méthodes servant à construire lesdites lignées cellulaires et leur utilisation dans des systèmes de criblage.
Hoefer Milan
Ludwig Jost
Schwanewilm Petra
Subik Julius
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoefer Milan
University Of South Bohemia
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