Yeast strains for protein production

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) C07K 14/39 (2006.01) C12N 1/19 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/80 (2006.01) C12N 15/81 (2006.01) C12N 15/90 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2705925

Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression systems are useful for increased cellular productivity of transformed cell lines and for production of recombinant glycoproteins at industrial scale.

L'invention concerne un procédé et un système pour des systèmes d'expression, basés sur les souches auxotrophes ade1 et ade2 de levure et de champignon, notamment P. pastoris. Les systèmes d'expression sont utiles pour augmenter la productivité cellulaire de lignées cellulaires transformées et pour produire des glycoprotéines recombinantes à l'échelle industrielle.

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