Yopm as delivery vehicle for cargo molecules and as...

Details Yopm as delivery vehicle for cargo molecules and as... Yopm as delivery vehicle for cargo molecules and as...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2712511

The present invention relates to the use of Yersinia outer protein M (YopM), a YopM fragment, or a YopM variant, which is capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for delivering a cargo molecule across the membrane to the cytosol of a cell. The present invention also relates to a pharmaceutical composition comprising YopM, a YopM fragment, or a YopM variant being capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for the regulation of inflammatory reactions of the immune system and the treatment of diseases caused by autoimmunity of the host. The present invention further relates to a YopM fragment or variant, which is capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirements of additional factors as well as such proteins or YopM linked to a cargo molecule.

Cette invention concerne lutilisation de la protéine M externe de Yersinia (YopM), dun fragment de la protéine YopM ou dun variant de la protéine YopM, qui est capable de pénétrer automatiquement la membrane cellulaire et de sintégrer dans le cytosol cellulaire sans nécessiter dautres facteurs pour administrer une molécule cargo à travers la membrane vers le cytosol dune cellule. Linvention concerne également une composition pharmaceutique comprenant la protéine YopM, un fragment de la protéine YopM ou un variant de la protéine YopM capable de pénétrer automatiquement la membrane cellulaire et de sintégrer dans le cytosol cellulaire sans nécessiter dautres facteurs pour réguler les réactions inflammatoires du système immunitaire et le traitement des maladies causées par lauto-immunité de lhôte. Linvention concerne par ailleurs un fragment ou un variant de la protéine YopM, qui est capable de pénétrer automatiquement la membrane cellulaire et de sintégrer dans le cytosol cellulaire sans nécessiter dautres facteurs et ce type de protéines ou la protéine YopM fixée à une molécule cargo.

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