(z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors

Details (z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors (z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors

A - Human Necessities

61

K

A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/31 (2006.01) C07C 67/02 (2006.01) C07C 69/02 (2006.01) C07C 323/20 (2006.01) C07C 381/00 (2006.01)

Patent

CA 2375511

Compounds of formula (I) are provided wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl. The compounds are inhibitors of cyclooxygenase-2 activity, useful for treating inflamation and cyclooxygenase-mediated disorders.

L'invention concerne des composés de formule (I) dans laquelle R¿1?, R¿2?, R¿3? et R¿4? sont sélectionnés indépendamment l'un de l'autre dans un groupe comprenant hydrogène, halogène, hydroxyle, C¿1?-C¿8? alkyl, C¿1?-C¿6? alcoxy, nitro, cyano, acétoxy, amino, carboxy, sulfamyle, acylsulfamyle inférieur et trifluorométhyle. Ces composés sont des inhibiteurs de l'activité de la cyclo-oxygénase-2 qui servent à traiter les inflammations et les troubles induits par la cyclo-oxygénase.

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