Z-styryl sulfone anticancer agents

Details Z-styryl sulfone anticancer agents Z-styryl sulfone anticancer agents

C - Chemistry, Metallurgy

07

C

C07C 317/10 (2006.01) A61K 31/10 (2006.01) A61P 35/00 (2006.01) C07C 323/07 (2006.01)

Patent

CA 2368653

(Z)-styryl benzylsulfones of formula (I) are useful as anticancer agents: wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro; and R3 and R4 are independently selected from the group consisting of hydrogen, lower akyl, nitro, chloro, bromo, iodo and fluoro; provided that at least one of R1 or R2 is hydrogen. The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones.

les (Z)-styryl benzylsulfones de formule (I) conviennent comme agents anticancéreux. Dans cette formule, R1 est pris dans le groupe hydrogène, chloro et nitro; R2 est pris dans le groupe comprenant hydrogène, alkyle inférieur, alkoxy, inférieur, chloro, bromo, iodo et fluoro; et R3 et R4 sont pris indépendamment dans le groupe comprenant hydrogène, alkyle inférieur, nitro, chloro, bromo, iodo et fluoro; à condition que l'un au moins de R1 ou de R2 soit hydrogène. Les (Z)-styryl benzylsulfures correspondants sont utiles comme intermédiaires pour la préparation de (Z)-styryl benzyl sulfones actifs au plan biologique.

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