C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2413475
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
De façon étonnante, nous avons découvert que l'expression de ZAP-70, aussi bien au niveau de la protéine que de l'ARNm, est un indicateur des sous-groupes cliniques de patients atteints de leucémie lymphoïde chronique / petit lymphome lymphocytaire (LLC/PLL). En particulier, une expression élevée de ZAP-70 est indicatrice d'un profil non muté des gènes des immunoglobulines chez les patients atteints de LLC/PLL. Sont décrites des méthodes permettant de distinguer les sous-groupes cliniques de LLC/PLL, en déterminant si l'ARNm et la protéine de ZAP-70 sont surexprimés chez les sujets.
Barry Todd S.
Rosenwald Andreas
Staudt Louis M.
Wiestner Adrian
Wilson Wyndham
Smart & Biggar
The Government Of The United States Of America As Represented By
LandOfFree
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