Zebrafish models for alzheimer's disease

Details Zebrafish models for alzheimer's disease Zebrafish models for alzheimer's disease

A - Human Necessities

01

K

A01K 67/027 (2006.01)

Patent

CA 2596267

The present invention relates to zebrafish models for Alzheimer's disease that allow recapitulation of pathologies associated with Alzheimer's disease. This invention also relates to methods for screening of compounds for their ability to modulate a pathology associated with Alzheimer's disease in vivo in a whole vertebrate organism. The present invention further relates to methods of identifying gene targets for compounds that modulate a pathology associated with Alzheimer's disease.

L'invention se rapporte à des modèles poisson zèbre de la maladie d'Alzheimer, permettant la récapitulation des pathologies associées à la maladie d'Alzheimer. L'invention concerne également des procédés permettant le criblage de composés en fonction de leur capacité de moduler une pathologie associée à la maladie d'Alzheimer, in vivo dans un organisme vertébré complet. L'invention concerne en outre des procédés permettant d'identifier des cibles génétiques pour les composés modulant une pathologie associée à la maladie d'Alzheimer.

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