Zero length cross-linking of proteins

Details Zero length cross-linking of proteins Zero length cross-linking of proteins

C - Chemistry, Metallurgy

07

K

C07K 1/107 (2006.01) C07K 1/02 (2006.01) C07K 17/00 (2006.01) G01N 33/543 (2006.01) G01N 33/544 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2356003

A method of cross-linking protein molecules. The method involves lyophilizing a solution of at least one protein; maintaining the lyophilized solid under vacuum; heating the lyophilized solid under vacuum to an elevated temperature effective to cause cross-linking without denaturing of the protein or proteins; and cooling the product and releasing the vacuum. The method produces cross-linking without the use of activating compounds or cross-linking molecules. The invention also relates to novel cross-linked proteins produced by the method.

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